This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ALAS1-20-RE | 20 (40 μL) | 200 μL |  |
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| ALAS1-20-OR | 20 (40 μL) | 200 μL |  |
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| ALAS1-20-GO | 20 (40 μL) | 200 μL |  |
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| ALAS1-20-GR | 20 (40 μL) | 200 μL |  |
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| ALAS1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Gene Symbol : ALAS1
Gene Name : 5'-aminolevulinate synthase 1
Chromosome : CHR 3: 521,980,82-522,143,26
Locus : 3p21.2
Alt. Genes : PREB
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