ALDH18A1 FISH Probe

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ALDH18A1-20-RE 20 (40 μL) 200 μL color Request Pricing
ALDH18A1-20-OR 20 (40 μL) 200 μL color Request Pricing
ALDH18A1-20-GO 20 (40 μL) 200 μL color Request Pricing
ALDH18A1-20-GR 20 (40 μL) 200 μL color Request Pricing
ALDH18A1-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol : ALDH18A1

Gene Name : Aldehyde dehydrogenase 18 family member A1

Chromosome : CHR 10: 956,568,09-956,059,28

Locus : 10q24.1

Alt. Genes : LRPPRC

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