ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ANAPC10-20-RE | 20 (40 μL) | 200 μL |  |
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| ANAPC10-20-OR | 20 (40 μL) | 200 μL |  |
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| ANAPC10-20-GO | 20 (40 μL) | 200 μL |  |
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| ANAPC10-20-GR | 20 (40 μL) | 200 μL |  |
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| ANAPC10-20-AQ | 20 (40 μL) | 200 μL |  |
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ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Gene Symbol : ANAPC10
Gene Name : Anaphase promoting complex subunit 10
Chromosome : CHR 4: 145,098,540-144,967,116
Locus : 4q31.21
Alt. Genes : FEM1B
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