A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ANAPC2-20-RE | 20 (40 μL) | 200 μL |  |
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| ANAPC2-20-OR | 20 (40 μL) | 200 μL |  |
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| ANAPC2-20-GO | 20 (40 μL) | 200 μL |  |
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| ANAPC2-20-GR | 20 (40 μL) | 200 μL |  |
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| ANAPC2-20-AQ | 20 (40 μL) | 200 μL |  |
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A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
Gene Symbol : ANAPC2
Gene Name : Anaphase promoting complex subunit 2
Chromosome : CHR 9: 137,188,604-137,174,783
Locus : 9q34.3
Alt. Genes : PREB
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