Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APEX1-20-RE | 20 (40 μL) | 200 μL |  |
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| APEX1-20-OR | 20 (40 μL) | 200 μL |  |
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| APEX1-20-GO | 20 (40 μL) | 200 μL |  |
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| APEX1-20-GR | 20 (40 μL) | 200 μL |  |
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| APEX1-20-AQ | 20 (40 μL) | 200 μL |  |
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Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Gene Symbol : APEX1
Gene Name : Apurinic/apyrimidinic endodeoxyribonuclease 1
Chromosome : CHR 14: 204,551,30-204,577,71
Locus : 14q11.2
Alt. Genes : RAD50
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