This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| API5-20-RE | 20 (40 μL) | 200 μL |  |
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| API5-20-OR | 20 (40 μL) | 200 μL |  |
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| API5-20-GO | 20 (40 μL) | 200 μL |  |
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| API5-20-GR | 20 (40 μL) | 200 μL |  |
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| API5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Symbol : API5
Gene Name : Apoptosis inhibitor 5
Chromosome : CHR 11: 433,119,54-433,445,29
Locus : 11p12
Alt. Genes : TRIM10
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