This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ARHGAP8-20-RE | 20 (40 μL) | 200 μL |  |
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| ARHGAP8-20-OR | 20 (40 μL) | 200 μL |  |
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| ARHGAP8-20-GO | 20 (40 μL) | 200 μL |  |
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| ARHGAP8-20-GR | 20 (40 μL) | 200 μL |  |
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| ARHGAP8-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Gene Symbol : ARHGAP8
Gene Name : Rho GTPase activating protein 8
Chromosome : CHR 22: 447,525,57-448,627,83
Locus : 22q13.31
Alt. Genes : RBM7
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