This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ARNT-20-RE | 20 (40 μL) | 200 μL |  |
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| ARNT-20-OR | 20 (40 μL) | 200 μL |  |
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| ARNT-20-GO | 20 (40 μL) | 200 μL |  |
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| ARNT-20-GR | 20 (40 μL) | 200 μL |  |
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| ARNT-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Gene Symbol : ARNT
Gene Name : Aryl hydrocarbon receptor nuclear translocator
Chromosome : CHR 1: 150,876,767-150,809,704
Locus : 1q21.3
Alt. Genes : OPTN
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