This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ASIC2-20-RE | 20 (40 μL) | 200 μL |  |
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| ASIC2-20-OR | 20 (40 μL) | 200 μL |  |
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| ASIC2-20-GO | 20 (40 μL) | 200 μL |  |
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| ASIC2-20-GR | 20 (40 μL) | 200 μL |  |
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| ASIC2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Gene Symbol : ASIC2
Gene Name : Acid sensing ion channel subunit 2
Chromosome : CHR 17: 341,568,05-330,130,86
Locus : 17q11.2-q12
Alt. Genes : PDZK1IP1
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