The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ASPSCR1-20-RE | 20 (40 μL) | 200 μL |  |
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| ASPSCR1-20-OR | 20 (40 μL) | 200 μL |  |
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| ASPSCR1-20-GO | 20 (40 μL) | 200 μL |  |
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| ASPSCR1-20-GR | 20 (40 μL) | 200 μL |  |
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| ASPSCR1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
Gene Symbol : ASPSCR1
Gene Name : ASPSCR1, UBX domain containing tether for SLC2A4
Chromosome : CHR 17: 819,775,49-820,189,28
Locus : 17q25.3
Alt. Genes : EBI3
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