The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ATF6B-20-RE | 20 (40 μL) | 200 μL |  |
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| ATF6B-20-OR | 20 (40 μL) | 200 μL |  |
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| ATF6B-20-GO | 20 (40 μL) | 200 μL |  |
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| ATF6B-20-GR | 20 (40 μL) | 200 μL |  |
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| ATF6B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Symbol : ATF6B
Gene Name : Activating transcription factor 6 beta
Chromosome : CHR 6: 321,282,39-321,152,67
Locus : 6p21.32
Alt. Genes : YAF2
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