Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ATG4B-20-RE | 20 (40 μL) | 200 μL |  |
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| ATG4B-20-OR | 20 (40 μL) | 200 μL |  |
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| ATG4B-20-GO | 20 (40 μL) | 200 μL |  |
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| ATG4B-20-GR | 20 (40 μL) | 200 μL |  |
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| ATG4B-20-AQ | 20 (40 μL) | 200 μL |  |
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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : ATG4B
Gene Name : Autophagy related 4B cysteine peptidase
Chromosome : CHR 2: 241,637,611-241,673,856
Locus : 2q37.3
Alt. Genes : PREB
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