This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BAMBI-20-RE | 20 (40 μL) | 200 μL |  |
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| BAMBI-20-OR | 20 (40 μL) | 200 μL |  |
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| BAMBI-20-GO | 20 (40 μL) | 200 μL |  |
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| BAMBI-20-GR | 20 (40 μL) | 200 μL |  |
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| BAMBI-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Gene Symbol : BAMBI
Gene Name : BMP and activin membrane bound inhibitor
Chromosome : CHR 10: 286,774,94-286,829,38
Locus : 10p12.1
Alt. Genes : ZNF263
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