This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BBC3-20-RE | 20 (40 μL) | 200 μL |  |
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| BBC3-20-OR | 20 (40 μL) | 200 μL |  |
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| BBC3-20-GO | 20 (40 μL) | 200 μL |  |
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| BBC3-20-GR | 20 (40 μL) | 200 μL |  |
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| BBC3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Symbol : BBC3
Gene Name : BCL2 binding component 3
Chromosome : CHR 19: 472,329,97-472,208,21
Locus : 19q13.32
Alt. Genes : RCL1
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