This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BCAR4-20-RE | 20 (40 μL) | 200 μL |  |
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| BCAR4-20-OR | 20 (40 μL) | 200 μL |  |
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| BCAR4-20-GO | 20 (40 μL) | 200 μL |  |
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| BCAR4-20-GR | 20 (40 μL) | 200 μL |  |
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| BCAR4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
Gene Symbol : BCAR4
Gene Name : Breast cancer anti-estrogen resistance 4 (non-protein coding)
Chromosome : CHR 16: 118,288,31-118,198,29
Locus : 16p13.13
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