This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BCL11A-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| BCL11A-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| BCL11A-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| BCL11A-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| BCL11A-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : BCL11A
Gene Name : B-cell CLL/lymphoma 11A
Chromosome : CHR 2: 605,534,97-604,511,66
Locus : 2p16.1
Alt. Genes : RBM12
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.