The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BCL6-20-RE | 20 (40 μL) | 200 μL |  |
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| BCL6-20-OR | 20 (40 μL) | 200 μL |  |
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| BCL6-20-GO | 20 (40 μL) | 200 μL |  |
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| BCL6-20-GR | 20 (40 μL) | 200 μL |  |
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| BCL6-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Gene Symbol : BCL6
Gene Name : B-cell CLL/lymphoma 6
Chromosome : CHR 3: 187,745,724-187,721,376
Locus : 3q27.3
Alt. Genes : FEM1B
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