This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BGLAP-20-RE | 20 (40 μL) | 200 μL |  |
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| BGLAP-20-OR | 20 (40 μL) | 200 μL |  |
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| BGLAP-20-GO | 20 (40 μL) | 200 μL |  |
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| BGLAP-20-GR | 20 (40 μL) | 200 μL |  |
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| BGLAP-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Gene Symbol : BGLAP
Gene Name : Bone gamma-carboxyglutamate protein
Chromosome : CHR 1: 156,241,961-156,243,331
Locus : 1q22
Alt. Genes : AASS
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