This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BMI1-20-RE | 20 (40 μL) | 200 μL |  |
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| BMI1-20-OR | 20 (40 μL) | 200 μL |  |
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| BMI1-20-GO | 20 (40 μL) | 200 μL |  |
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| BMI1-20-GR | 20 (40 μL) | 200 μL |  |
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| BMI1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Gene Symbol : BMI1
Gene Name : BMI1 proto-oncogene, polycomb ring finger
Chromosome : CHR 10: 223,212,09-223,314,84
Locus : 10p12.2
Alt. Genes : CFM1
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