This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]
SKU | Test Kits | Buffer | Dye Color | Order Now |
---|---|---|---|---|
BMP15-20-RE | 20 (40 μL) | 200 μL | Request Pricing | |
BMP15-20-OR | 20 (40 μL) | 200 μL | Request Pricing | |
BMP15-20-GO | 20 (40 μL) | 200 μL | Request Pricing | |
BMP15-20-GR | 20 (40 μL) | 200 μL | Request Pricing | |
BMP15-20-AQ | 20 (40 μL) | 200 μL | Request Pricing |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]
Gene Symbol : BMP15
Gene Name : Bone morphogenetic protein 15
Chromosome : CHR X: 509,107,34-509,166,40
Locus : Xp11.22
Alt. Genes : PREB
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