The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CAD-20-RE | 20 (40 μL) | 200 μL |  |
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| CAD-20-OR | 20 (40 μL) | 200 μL |  |
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| CAD-20-GO | 20 (40 μL) | 200 μL |  |
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| CAD-20-GR | 20 (40 μL) | 200 μL |  |
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| CAD-20-AQ | 20 (40 μL) | 200 μL |  |
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The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Gene Symbol : CAD
Gene Name : Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Chromosome : CHR 2: 272,172,56-272,437,91
Locus : 2p23.3
Alt. Genes : PREB
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