The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CARD8-20-RE | 20 (40 μL) | 200 μL |  |
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| CARD8-20-OR | 20 (40 μL) | 200 μL |  |
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| CARD8-20-GO | 20 (40 μL) | 200 μL |  |
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| CARD8-20-GR | 20 (40 μL) | 200 μL |  |
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| CARD8-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Gene Symbol : CARD8
Gene Name : Caspase recruitment domain family member 8
Chromosome : CHR 19: 482,562,68-482,031,47
Locus : 19q13.33
Alt. Genes : LAMC3
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