CBFA2T2 FISH Probe

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
CBFA2T2-20-RE 20 (40 μL) 200 μL color Request Pricing
CBFA2T2-20-OR 20 (40 μL) 200 μL color Request Pricing
CBFA2T2-20-GO 20 (40 μL) 200 μL color Request Pricing
CBFA2T2-20-GR 20 (40 μL) 200 μL color Request Pricing
CBFA2T2-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol : CBFA2T2

Gene Name : CBFA2/RUNX1 translocation partner 2

Chromosome : CHR 20: 334,900,67-336,500,30

Locus : 20q11.21-q11.22

Alt. Genes : ZNF263

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