The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CD3E-20-RE | 20 (40 μL) | 200 μL |  |
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| CD3E-20-OR | 20 (40 μL) | 200 μL |  |
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| CD3E-20-GO | 20 (40 μL) | 200 μL |  |
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| CD3E-20-GR | 20 (40 μL) | 200 μL |  |
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| CD3E-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Gene Symbol : CD3E
Gene Name : CD3e molecule
Chromosome : CHR 11: 118,304,579-118,316,174
Locus : 11q23.3
Alt. Genes : SUGP2
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