CDC45 FISH Probe

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
CDC45-20-RE 20 (40 μL) 200 μL color Request Pricing
CDC45-20-OR 20 (40 μL) 200 μL color Request Pricing
CDC45-20-GO 20 (40 μL) 200 μL color Request Pricing
CDC45-20-GR 20 (40 μL) 200 μL color Request Pricing
CDC45-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Details

Gene Symbol : CDC45

Gene Name : Cell division cycle 45

Chromosome : CHR 22: 194,792,77-195,206,11

Locus : 22q11.21

Alt. Genes : PREB

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