This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDKN2B-AS1-20-RE | 20 (40 μL) | 200 μL |  |
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| CDKN2B-AS1-20-OR | 20 (40 μL) | 200 μL |  |
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| CDKN2B-AS1-20-GO | 20 (40 μL) | 200 μL |  |
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| CDKN2B-AS1-20-GR | 20 (40 μL) | 200 μL |  |
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| CDKN2B-AS1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
Gene Symbol : CDKN2B-AS1
Gene Name : CDKN2B antisense RNA 1
Chromosome : CHR 9: 219,947,90-221,210,96
Locus : 9p21.3
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