This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CENPJ-20-RE | 20 (40 μL) | 200 μL |  |
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| CENPJ-20-OR | 20 (40 μL) | 200 μL |  |
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| CENPJ-20-GO | 20 (40 μL) | 200 μL |  |
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| CENPJ-20-GR | 20 (40 μL) | 200 μL |  |
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| CENPJ-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Symbol : CENPJ
Gene Name : Centromere protein J
Chromosome : CHR 13: 249,228,88-248,822,73
Locus : 13q12.12-q12.13
Alt. Genes : AKAP9
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