This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CES1-20-RE | 20 (40 μL) | 200 μL |  |
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| CES1-20-OR | 20 (40 μL) | 200 μL |  |
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| CES1-20-GO | 20 (40 μL) | 200 μL |  |
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| CES1-20-GR | 20 (40 μL) | 200 μL |  |
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| CES1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Symbol : CES1
Gene Name : Carboxylesterase 1
Chromosome : CHR 16: 558,331,85-558,028,50
Locus : 16q12.2
Alt. Genes : RRAGB
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