This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHD3-20-RE | 20 (40 μL) | 200 μL |  |
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| CHD3-20-OR | 20 (40 μL) | 200 μL |  |
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| CHD3-20-GO | 20 (40 μL) | 200 μL |  |
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| CHD3-20-GR | 20 (40 μL) | 200 μL |  |
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| CHD3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Symbol : CHD3
Gene Name : Chromodomain helicase DNA binding protein 3
Chromosome : CHR 17: 788,476,3-791,275,6
Locus : 17p13.1
Alt. Genes : TRIM28
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