This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHMP2B-20-RE | 20 (40 μL) | 200 μL |  |
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| CHMP2B-20-OR | 20 (40 μL) | 200 μL |  |
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| CHMP2B-20-GO | 20 (40 μL) | 200 μL |  |
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| CHMP2B-20-GR | 20 (40 μL) | 200 μL |  |
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| CHMP2B-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
Gene Symbol : CHMP2B
Gene Name : Charged multivesicular body protein 2B
Chromosome : CHR 3: 872,272,62-872,555,47
Locus : 3p11.2
Alt. Genes : FEM1B
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