Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CILP-20-RE | 20 (40 μL) | 200 μL |  |
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| CILP-20-OR | 20 (40 μL) | 200 μL |  |
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| CILP-20-GO | 20 (40 μL) | 200 μL |  |
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| CILP-20-GR | 20 (40 μL) | 200 μL |  |
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| CILP-20-AQ | 20 (40 μL) | 200 μL |  |
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Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
Gene Symbol : CILP
Gene Name : Cartilage intermediate layer protein
Chromosome : CHR 15: 652,116,07-651,959,98
Locus : 15q22.31
Alt. Genes : FEM1B
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