The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CITED4-20-RE | 20 (40 μL) | 200 μL |  |
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| CITED4-20-OR | 20 (40 μL) | 200 μL |  |
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| CITED4-20-GO | 20 (40 μL) | 200 μL |  |
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| CITED4-20-GR | 20 (40 μL) | 200 μL |  |
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| CITED4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
Gene Symbol : CITED4
Gene Name : Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Chromosome : CHR 1: 408,623,45-408,610,55
Locus : 1p35-p34
Alt. Genes : PSME3
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