This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| COL25A1-20-RE | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-OR | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-GO | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-GR | 20 (40 μL) | 200 μL |  |
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| COL25A1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Symbol : COL25A1
Gene Name : Collagen type XXV alpha 1 chain
Chromosome : CHR 4: 109,302,736-108,808,724
Locus : 4q25
Alt. Genes : FARP1
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