The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| COMP-20-RE | 20 (40 μL) | 200 μL |  |
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| COMP-20-OR | 20 (40 μL) | 200 μL |  |
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| COMP-20-GO | 20 (40 μL) | 200 μL |  |
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| COMP-20-GR | 20 (40 μL) | 200 μL |  |
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| COMP-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]
Gene Symbol : COMP
Gene Name : Cartilage oligomeric matrix protein
Chromosome : CHR 19: 187,913,04-187,827,72
Locus : 19p13.11
Alt. Genes : RBM12
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