This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CRADD-20-RE | 20 (40 μL) | 200 μL |  |
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| CRADD-20-OR | 20 (40 μL) | 200 μL |  |
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| CRADD-20-GO | 20 (40 μL) | 200 μL |  |
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| CRADD-20-GR | 20 (40 μL) | 200 μL |  |
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| CRADD-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Symbol : CRADD
Gene Name : CASP2 and RIPK1 domain containing adaptor with death domain
Chromosome : CHR 12: 936,773,41-938,948,39
Locus : 12q22
Alt. Genes : CLEC3A
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