This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CRB1-20-RE | 20 (40 μL) | 200 μL |  |
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| CRB1-20-OR | 20 (40 μL) | 200 μL |  |
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| CRB1-20-GO | 20 (40 μL) | 200 μL |  |
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| CRB1-20-GR | 20 (40 μL) | 200 μL |  |
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| CRB1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Gene Symbol : CRB1
Gene Name : Crumbs 1, cell polarity complex component
Chromosome : CHR 1: 197,201,461-197,478,454
Locus : 1q31.3
Alt. Genes : ZNF263
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