This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CRK-20-RE | 20 (40 μL) | 200 μL |  |
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| CRK-20-OR | 20 (40 μL) | 200 μL |  |
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| CRK-20-GO | 20 (40 μL) | 200 μL |  |
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| CRK-20-GR | 20 (40 μL) | 200 μL |  |
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| CRK-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Gene Symbol : CRK
Gene Name : CRK proto-oncogene, adaptor protein
Chromosome : CHR 17: 145,626,6-142,135,2
Locus : 17p13.3
Alt. Genes : TRAP1
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