This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CTNND2-20-RE | 20 (40 μL) | 200 μL |  |
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| CTNND2-20-OR | 20 (40 μL) | 200 μL |  |
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| CTNND2-20-GO | 20 (40 μL) | 200 μL |  |
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| CTNND2-20-GR | 20 (40 μL) | 200 μL |  |
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| CTNND2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Gene Symbol : CTNND2
Gene Name : Catenin delta 2
Chromosome : CHR 5: 119,040,66-109,718,39
Locus : 5p15.2
Alt. Genes : YAF2
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