This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CUL4B-20-RE | 20 (40 μL) | 200 μL |  |
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| CUL4B-20-OR | 20 (40 μL) | 200 μL |  |
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| CUL4B-20-GO | 20 (40 μL) | 200 μL |  |
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| CUL4B-20-GR | 20 (40 μL) | 200 μL |  |
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| CUL4B-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : CUL4B
Gene Name : Cullin 4B
Chromosome : CHR X: 120,575,828-120,524,588
Locus : Xq24
Alt. Genes : FEM1B
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