This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DAB2-20-RE | 20 (40 μL) | 200 μL |  |
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| DAB2-20-OR | 20 (40 μL) | 200 μL |  |
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| DAB2-20-GO | 20 (40 μL) | 200 μL |  |
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| DAB2-20-GR | 20 (40 μL) | 200 μL |  |
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| DAB2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Symbol : DAB2
Gene Name : DAB2, clathrin adaptor protein
Chromosome : CHR 5: 394,252,32-393,716,73
Locus : 5p13.1
Alt. Genes : ARPC2
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