This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DENND5A-20-RE | 20 (40 μL) | 200 μL |  |
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| DENND5A-20-OR | 20 (40 μL) | 200 μL |  |
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| DENND5A-20-GO | 20 (40 μL) | 200 μL |  |
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| DENND5A-20-GR | 20 (40 μL) | 200 μL |  |
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| DENND5A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. [provided by RefSeq, Feb 2017]
Gene Symbol : DENND5A
Gene Name : DENN domain containing 5A
Chromosome : CHR 11: 926,533,4-913,882,4
Locus : 11p15.4
Alt. Genes : FEM1B
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