This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DHCR24-20-RE | 20 (40 μL) | 200 μL |  |
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| DHCR24-20-OR | 20 (40 μL) | 200 μL |  |
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| DHCR24-20-GO | 20 (40 μL) | 200 μL |  |
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| DHCR24-20-GR | 20 (40 μL) | 200 μL |  |
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| DHCR24-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Symbol : DHCR24
Gene Name : 24-dehydrocholesterol reductase
Chromosome : CHR 1: 548,872,47-548,496,26
Locus : 1p32.3
Alt. Genes : PREB
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