Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DHFR-20-RE | 20 (40 μL) | 200 μL |  |
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| DHFR-20-OR | 20 (40 μL) | 200 μL |  |
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| DHFR-20-GO | 20 (40 μL) | 200 μL |  |
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| DHFR-20-GR | 20 (40 μL) | 200 μL |  |
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| DHFR-20-AQ | 20 (40 μL) | 200 μL |  |
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Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Gene Symbol : DHFR
Gene Name : Dihydrofolate reductase
Chromosome : CHR 5: 806,549,80-806,262,25
Locus : 5q14.1
Alt. Genes : FEM1B
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