This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DIABLO-20-RE | 20 (40 μL) | 200 μL |  |
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| DIABLO-20-OR | 20 (40 μL) | 200 μL |  |
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| DIABLO-20-GO | 20 (40 μL) | 200 μL |  |
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| DIABLO-20-GR | 20 (40 μL) | 200 μL |  |
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| DIABLO-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Gene Symbol : DIABLO
Gene Name : Diablo IAP-binding mitochondrial protein
Chromosome : CHR 12: 122,227,533-122,207,661
Locus : 12q24.31
Alt. Genes : RBM12
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