This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DKK1-20-RE | 20 (40 μL) | 200 μL |  |
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| DKK1-20-OR | 20 (40 μL) | 200 μL |  |
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| DKK1-20-GO | 20 (40 μL) | 200 μL |  |
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| DKK1-20-GR | 20 (40 μL) | 200 μL |  |
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| DKK1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Gene Symbol : DKK1
Gene Name : Dickkopf WNT signaling pathway inhibitor 1
Chromosome : CHR 10: 523,142,80-523,176,56
Locus : 10q21.1
Alt. Genes : ABI2
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