Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DNAJC24-20-RE | 20 (40 μL) | 200 μL |  |
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| DNAJC24-20-OR | 20 (40 μL) | 200 μL |  |
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| DNAJC24-20-GO | 20 (40 μL) | 200 μL |  |
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| DNAJC24-20-GR | 20 (40 μL) | 200 μL |  |
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| DNAJC24-20-AQ | 20 (40 μL) | 200 μL |  |
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Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
Gene Symbol : DNAJC24
Gene Name : DnaJ heat shock protein family (Hsp40) member C24
Chromosome : CHR 11: 313,698,28-314,328,34
Locus : 11p13
Alt. Genes : HIPK3
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