The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DOCK2-20-RE | 20 (40 μL) | 200 μL |  |
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| DOCK2-20-OR | 20 (40 μL) | 200 μL |  |
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| DOCK2-20-GO | 20 (40 μL) | 200 μL |  |
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| DOCK2-20-GR | 20 (40 μL) | 200 μL |  |
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| DOCK2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
Gene Symbol : DOCK2
Gene Name : Dedicator of cytokinesis 2
Chromosome : CHR 5: 169,637,246-170,083,381
Locus : 5q35.1
Alt. Genes : FEM1B
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