This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DPH3-20-RE | 20 (40 μL) | 200 μL |  |
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| DPH3-20-OR | 20 (40 μL) | 200 μL |  |
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| DPH3-20-GO | 20 (40 μL) | 200 μL |  |
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| DPH3-20-GR | 20 (40 μL) | 200 μL |  |
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| DPH3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Gene Symbol : DPH3
Gene Name : Diphthamide biosynthesis 3
Chromosome : CHR 3: 162,649,88-162,570,60
Locus : 3p25.1
Alt. Genes : RBM12
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