This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DPH5-20-RE | 20 (40 μL) | 200 μL |  |
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| DPH5-20-OR | 20 (40 μL) | 200 μL |  |
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| DPH5-20-GO | 20 (40 μL) | 200 μL |  |
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| DPH5-20-GR | 20 (40 μL) | 200 μL |  |
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| DPH5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : DPH5
Gene Name : Diphthamide biosynthesis 5
Chromosome : CHR 1: 101,025,805-100,989,622
Locus : 1p21.2
Alt. Genes : ENAM
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