This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DPYSL2-20-RE | 20 (40 μL) | 200 μL |  |
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| DPYSL2-20-OR | 20 (40 μL) | 200 μL |  |
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| DPYSL2-20-GO | 20 (40 μL) | 200 μL |  |
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| DPYSL2-20-GR | 20 (40 μL) | 200 μL |  |
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| DPYSL2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Symbol : DPYSL2
Gene Name : Dihydropyrimidinase like 2
Chromosome : CHR 8: 265,141,92-266,581,76
Locus : 8p21.2
Alt. Genes : PDZK1IP1
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